Curriculum vitae family name : Martens



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CURRICULUM VITAE



Family name : Martens
Christian names : Gerardus Julianus Maria
Date of birth : July 28, 1954
Place of birth : Asten (N-Br), The Netherlands
Sex : Male
Marital Status : Married to Anneke B.M. Kersten, 21 April 1982; one son (Marijn­), 11 April 1986
Nationality : Dutch
Address home : Ubbergseveldweg 48,

6522 HH Nijmegen, The Netherlands.

Telephone number: 31-24-3227443
work : Department of Molecular Animal Physiology, Donders Institute for Neuroscience, Nijmegen Center for Molecular Life Sciences (NCMLS), Radboud University, Geert Grooteplein Zuid 28, RT 282, 6525 GA Nijmegen, The Netherlands.

Telephone number: 31-24-3610564; Telefax: 31-24-3615317;



e-mail: g.martens@ncmls.ru.nl


In brief



Gerard J.M. Martens received his training in Chemistry (1972-1979; with specialization in Biochemistry) at the University of Nijmegen, NL. During his PhD-period (1979-1982) he worked in the Department of Zoology (University of Nijmegen, NL) in the field of Biochemical Neuroendocrinology on the biosynthesis of peptide hormones (title of thesis: “Biosynthesis and release of peptides related to pro-opiomelanocortin by the pars intermedia of the am­phibian Xenopus laevis; cum laude). From 1982 to 1984 he performed post-doctoral research in the Molecular Neurobiology Section of the Departm­ent of Chemistry, University of Oregon, Eugene, OR, USA (Head: Prof.dr. Edward Herbert) on the regulation of neuropeptide genes. He received a C&C Huygens award (1984-1989) from the Netherlands Organi­za­ti­on for Scientific Research (NWO) and an NWO-PIONIER award (1990-1995) to perform research in the Depart­ments of Molecular Biology and Animal Physiology (University of Nijmegen, NL) on prohormone gene expression in neuroendocrine transducer cells. In 1993, he was appointed Full Professor in Zoology and became Head of the Department of Molecular Animal Physiology (University of Nijmegen, NL). He was Dean of the Faculty of Biology and he is currently Principal Investigator (PI) at the Donders Centre for Neuroscience and affiliated PI at the Nijmegen Center for Molecular Life Sciences (NCMLS), and Director of Education in Molecular Life Sciences. His current research focuses on the understanding of the molecular basis of neurodevelopmental disorders, including the analysis of a rat model for such disorders and of genetic variations in genomic DNAs from patients with neurodevelopmental psychiatric disorders.

EDUCATION
The certificate Atheneum-B (High School) was obtained in May 1972 at the Peelland College in Deurne (The Netherlands). In this year the study of Chemistry was started at the University of Nijmegen (KUN, The Netherlands). The Bachelor of Science (BSc) degree in Chemistry was awarded in May 1975. The Master of Science (MSc) degree in Chemistry/Biochemistry was obtained in February 1979 with Biochemistry (Prof. Dr. H.J. Hoenders and Prof. Dr. S.L. Bonting) as principal subject and Animal Physiology (Dr. B.G. Jenks and Prof. Dr. van Overbeeke) and Biophysical Chemis­try (Prof. Dr. C.W. Hilbers) as subsidiary subjects. During the Masters period the certifica­tes Health Physics for C laboratory and First Degree Qualification for Education in Chemis­try were obtained. From April 1979 to April 1982 research towards the degree of Doctor of Philosophy (PhD) was conducted in the Department of Zoology, University of Nijmegen, The Netherlands, under the direction of Dr. B.G. Jenks and Prof. Dr. A.P. van Overbeeke. The Ph.D. degree in Science was obtained in May 1982 (cum laude). From August 1982 to October 1984 post-doctoral research was performed in the Department of Chemistry, University of Oregon, Eugene, Oregon, USA, under the direction of the late Prof. Dr. E. Herbert. From November 1984 to November 1989 research supported by a C&C Huygens Award of the Nether­lands Organization for Scientific Research (NWO) was performed in the Depart­ments of Animal Physiology and Molecular Biology, University of Nijmegen, The Nether­lands. From November 1989 to 1995 research was performed in the Department of Animal Physiolo­gy, University of Nijmegen, The Netherlands; this research was supported by a PIONIER program of NWO.
Degrees: Bachelor of Science (Chemistry), June 1975, University of Nijmegen, The Netherlands.

Master of Science (Biochemistry), February 1979, University of Nijmegen, The Netherlands.

Doctor of Philosophy (cum laude, Science), May 1982, University of Nijme­gen, The Netherlands.

RESEARCH AND PROFESSIONAL EXPERIENCE
1976-1979: Teaching assistant in Chemistry/Biophysical Chemistry; University of Nijme­gen, The Netherlands.

1979-1982: PhD Fellow; Department of Zoology, University of Nijmegen, The Nether­lands; Biochemistry, Neuroendocrinology, Pharmacology.

1982-1984: Post-doc; Department of Chemistry, University of Oregon, USA; Molecular Neuroendocrinology, Neurobiology.

1984-1989: Research Associate, Huygens Fellowship; Departments of Molecular Biology and Animal Physiology, University of Nijmegen, The Netherlands.

1989-1995: NWO-PIONIER fellow; Department of Molecular Animal Physiology; University of Nijmegen, The Netherlands.

1989-1993: Assistant Professor; Department of Animal Physiology, University of Nijme­gen, The Netherlands.

1993: Full Professor in Zoology; Faculty of Science, University of Nijmegen, The Netherlands.

1993-present: Head Department of Molecular Animal Physiology; University of Nijmegen, The Netherlands.

1996-1998: Vice-Dean of the Faculty of Biology; Faculty of Science, University of Nijmegen, The Nether­lands.

1998-2001: Dean of the Faculty of Biology; Faculty of Science, University of Nijmegen, The Netherlands.

2001-2008: Principal Investigator (PI) Nijmegen Center for Molecular Life Sciences (NCMLS), Radboud University, Nijmegen; since 2008: Affiliated PI.

2008-present: Principal Investigator (PI) Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen

2008-present: Director of Education in Molecular Life Sciences, Faculty of Science, Radboud University, Nijmegen

2012-present: Cofounder and Advisor of Drug Target ID, B.V., Nijmegen



MEMBERSHIPS OF COMMITTEES
Search Committees for new Professorships (Free University Amsterdam, University Utrecht, University of Amsterdam, Radboud University Nijmegen) (1995-present)
Chairman Committee Research Biology, Subfaculty of Biology; University of Nijmegen, The Netherlands ((1994-1996)
Coordinator of Commission of the European Unity (EU, Brussels, Belgium) EU-TMR Research Network ­­­(eight participants from seven EU countries) (1996-2001)
Member/Chairman Board of Research School Institute of Cellular Signaling (ICS), Nijmegen, The Netherlands (1997-1999)
Member NWO-Committee 'Alternatives for Experimental Animals' ('Alternatieven voor Dierproe­ven') (1998-2003)
Member KUN committee Animal Experiments ('Dierexperimenten', DEC) (1999-2001)
Chairman NWO-Committee Evaluation and Selection of NWO-ALW project grants (Section 8: Biomolecul­ar and cellular processes and structures) (1998-2000)
Member Board NWO-Medical Sciences (Division Hormonal Regulation and Neurosciences) (1999-2001)
Member NWO-Earth and Life Sciences Committee for Evaluation of Innovational Research (‘Vernieuwingsimpuls­’; VIDI) (2000-2002)
Responsible Expert Radioactivity, 6th Floor Research Tower (2001-present)
Member Scientific Advisory Board of Laboratory School (HLO), Nijmegen, The Netherlands (2001-present)
Chairman/Member of Scientific Board, Netherlands Institute for Brain Research, Amsterdam, The Netherlands (2002-2004)
Member NWO-Earth and Life Sciences Committee for Evaluation of Research Career Development Award/Innovational Research Incentives Scheme (‘Vernieuwingsimpuls’; VICI) (2002-2004)
Member Research Board (‘Researchraad’) NCMLS (2002-2004)
Member Committee Differentiation Courses Biosciences (D-team); Subfaculty Biology, University of Nijmegen, The Netherlands (2002)
Member Board and Chairman of Research Committee of Research School Nijmegen Institute for Neuroscienc­es (NIN), Nijmege­n, The Netherlands (2002-2005)

Member Committee Faculty of Science for Evaluation of Innovational Research

(VENI/VIDI/VICI), University of Nijmegen, The Netherlands (2003-2005)
Member Committee NCMLS for Evaluation of Innovational Research

(VENI/VIDI/VICI), University of Nijmegen, The Netherlands (2003-present)


Chairman Committee Guidance for a career as a researcher, Subfaculty of Biology; University of Nijmegen, The Netherlands (2003)
Member NWO-Earth and Life Sciences Committee for Evaluation of Innovational Research (‘Vernieuwingsimpuls­’;VENI) (2004-2005)
Chairman International Jury Antoine Faes Award, Antoine Faes Foundation, Turnhout, Belgium (2004-present)
Member NWO Committee Mozaiek (2004-present)
Advisor NWO Mozaiek workshops (2004-present)
Member of Temporary Advisory Committee (merger of NORI & NIBR), Netherlands Institute for Neuroscience, Amsterdam, The Netherlands (2005)
Member European Dementia Concensus Network (EDCON) (2005-2006)
Member Committee UMC for Structure of Cognitive Neuroscience, University of Nijmegen, The Netherlands (2005-present)
Member NWO Committee for selection of Rubicon candidates (2006-present)
Member Advisory Board Research School Neuroscience Amsterdam (Onderzoekschool Neurowetenschappen Amsterdam, ONWA) (2006-present)
Member Committee for setting up Master Track Tissue Reconstruction and Molecular Neurobiology, Technical Medicine, University Twente, Enschede, The Netherlands (2006-present)
Advisor Design Master Track Technical Medicine, University Twente, Enschede, The Netherlands (2006-present)
Member Evaluation (Audit) of Basic and Cellular Neurobiology (BCN) division of

Institute for Molecular and Cell Biology (IBMC, Porto, Portugal), 3-5 January 2007


Member Science Communication Committee, Faculty of Science, Radboud University, Nijmegen, The Netherlands (2004-present)
Organiser scientific meetings Molecular and Cellular Neuroscience, Radboud University, Nijmegen (2004-present)
Member committees thesis evaluation and thesis defense (1985-present)
Responsible Expert Radioactivity, 6th Floor Research Tower (NCMLS), Radboud University, Nijmegen (2001-present)
Member Grant Evaluation Committee, Donders Centre for Neuroscience (DCN), Radboud University, Nijmegen (2008-present)
Coodinator theme 2 (Learning, Memory and Plasticity) of Donders Centre for Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen (2008-present)
Vice-coordinator theme 3 (Cell growth and differentiation; subtheme: Genetics and epigenetic pathways of disease) of Nijmegen Centre for Molecular Life Sciences (NCMLS), Radboud University, Nijmegen (2008-present)
Director of Education in Molecular Life Sciences (MLW), Faculty of Science, Radboud University, Nijmegen (2008-present)
Member NWO-ZonMW Wetenschappelijke Kwaliteits Commissie (WKC) Dierproeven Begrensd III (DPBIII) (2009-2012)
Member DCN/NCMLS Committees to assist VENI/VIDI/VICI applicants
Member various UMC/RU Search Committees (e.g. recently Professor of Molecular Neurobiology; Assistant Professor of Molecular Neurobiology; Professor Neurophysiology; Associate Professor Biophysics, Assistant Professor Molecular Cell Imaging; Assistant Professor Cognitive Neuroscience-Optogenetics; Professor Analytical Chemistry)
Member Committee evaluation Assistant Professors (Cellular Animal Physiology, 2010; Organic Chemistry, 2012)
Member Committee selection AiO/Agiko positions DCN, 2011-present)
Member NWO-Earth and Life Sciences (ALW) Committee for Evaluation of Innovational Research (‘Vernieuwingsimpuls­’;VENI); (2010-2012)
Member ZonMW Topgrant Evaluation Committee (January 2012-present)

AWARDS FOR FUNDING OF RESEARCH
Netherlands Organization for the Advancement of Pure Research (ZWO), The Netherlands.

Stipend University of Oregon, Eugene, Oregon, USA

1982-1983

1 post-doc


Netherlands Organization for Scientific Research (NWO), The Netherlands.

Christiaan & Constatijn Huygens Award (comparable to Research Career Develop­ment Award).

Project title: Regulation of expression of genes coding for neuropeptides: proopiomelanocort­in (POMC) in the pars intermedia as a model system.

Project period: 1984-1989.

1 post-doc
Commission of the European Unity (EU), Brussels, Belgium.

Project title: Identification of transcriptional regulatory units in the proopiomelanocor­tin gene of the amphibian Xenopus laevis (together with Prof. Dr. H. Vaudry, Universi­té de Rouen, France).

Project period: 1986-1988.

1 post-doc


University of Nijmegen (poolproject), The Netherlands.

Poject title: Proopiomelanocortin gene transcription in the pars intermedia of Xenopus laevis (together with Prof. Dr. S.E. Wendelaar Bonga and Dr. B.G. Jenks, University of Nijmegen).

Project period: 1987-1991.

1 PhD student


National Institutes of Health (NIH), Bethesda, Maryland, USA.

R01 Research Grant.

Project title: Prohormone Gene Regulation in a Neuroen­docrine Cell.

Project period: 1987-1991.

1 PhD student, 1 technician
Netherlands Organization for Scientific Research (NWO), The Netherlands.

PIONIER project (PGS 82-188).

Project title: Gene Expression in Neuroendocrine Transducer Cells.

Project period: 1990-1994.

3 PhD students, 1 technician
Commission of the European Unity (EU), Brussels, Belgium.

BRIDGE-programme (BIOT CT91-0302).

Project title: Animal Cell Biotechnology - Identification of genes involved in sorting and secretion and their use to genetically engineer animal cells for the production of bioactive peptides (together with Dr. W.J.M. van de Ven (Leuven, Belgium), Dr. J.C. Hutton (Cambridge, Engeland), Dr. J. Bullerdiek (Bremen, Duitsland­), Dr. L. Lanfrancone (Perugia, Italië), Dr. G.D. Keizer (HBT, Leiden, The Netherlands) and Dr. J.A. van Mourik (CLB, Amsterdam, The Netherlands)).

Project period: 1992-1993.

7 post-docs
Netherlands Organization for Scientific Research (NWO), The Netherlands.

BION programme SLW-805/33/023-P (together with Prof. Dr. A.J. Durston, Hubrec­ht Laboratory, Utrecht and Prof. Dr. E.W. Roubos, Nijmegen).

Project title: Functional development of the brain and pituitary in Xenopus laevis; development of the pars intermedia in Xenopus laevis.

Project period: 1995-1999.

3 PhD studnets
Netherlands Organization for Scientific Research (NWO), Technology Foundation, 'Stichting voor de Technische Wetenschappen' (STW), Utrecht, The Netherlands.

STW project NCH22.­2726

'Generation of bioactive proteins in genetically enginee­red animal cells by the novel furin family of proprotein proces­sing enzymes' (together with Dr. W.J.M. van de Ven, Leuven, Belgium)

1995-1997

1 post-doc
Netherlands Organization for Scientific Research (NWO), Life Sciences, Stichting Levenswe­tenschappen (SLW), The Hague, The Netherlands.

NWO-SLW programme 805-33-151-P, project 805-33-150 (together with Prof. Dr. W.P.M. Geraerts/ Dr. A.B. Smit, VU Amsterdam; G.J.M. Martens as coordinator)

'Molecular mechanism of prohormone convertase regula­ti­on by the neu­roen­docrine chaperone 7B2'

1995-1999

2 PhD students
Glaxo Research Nederland, Zeist, The Netherlands.

GRN-grant 94-002 (together with Prof. Dr. J.P.H. Burbach, Rudolf Magnus Institute, Utrecht; G.J.M. Martens as coordinator)

'Understanding secretory pathways at the molecular level'

1995-1999

2 PhD students, 2 technicians
Netherlands Organization for Scientific Research (NWO), Medical Sciences, Gebied Medische Wetenschappen (GMW), The Hague, The Netherlands.

NWO-GMW project 903-46-145

'The role of the granin family mem­ber secretogra­nin-3 in prohor­mo­ne biosyn­thesis' 1996-1999

1 post-doc.


Commission of the European Unity (EU), Brussels, Belgium.

EU-TMR Research Network ERBF­M­RX­CT960023

'Molecular dissection of the regulated secretory pathway: protein sorting and secretory granule formation' (G.J.M. Martens as coordinator; together with Prof. Dr. Ph. Halban, Geneva, Switzerland; Dr. S. Tooze, London, England; Prof. Dr. K. Docherty­, Aberdeen, Scotland; Dr. E. Chanat, France, Dr. P. Rosa, Milan, Italy, Prof.Dr. W.J.M. Van de Ven, Leuven, Belgium, Prof. Dr. W. Huttner, Heidelberg/Dresden, Germany; eight participants from seven EU countries).

1996-2001

8 post-docs
Netherlands Organization for Scientific Research (NWO), Life Sciences, Stichting Levenswe­tenschappen (SLW), The Hague, The Netherlands.

NWO-SLW programma 805-33.210 'Molecular interactions in the regulated secretory pathway of (neuro)endocrine cells' (together with Prof. Dr. J.P.H. Burbach, Rudolf Magnus Institute, Utrecht); project 805-33.212-P

'Modulation of the microenvi­ronment in the TGN/secre­tory granule: the role of a novel accessory subunit of vacuolar H+-ATPa­se'

1996-2000

1 PhD student
Diabetes Fund Nederland, Amersfoort

DFN-grant 95-116 (together with Dr. A.R.M.M. Hermus, Faculty of Medical Sci­ences, Nijmegen)

'Hyperglyce­mia-induced dysfunc­tion of the secretory pathway in β-cells as a cause of impaired insulin secretion in NIDD­M'

1996-2000

1 PhD student, 1 technici­an.
Netherlands Organization for Scientific Research (NWO), Life Sciences, Stichting Levenswe­tenschappen (SLW), The Hague, The Netherlands.

NWO-SLW-project 805-17.291

'A cargo recep­tor for prohormone transport and sorting in the secreto­ry pathway of neuroen­docrine cells"

1997-2000

1 post-doc
Hersenstichting Nederland, The Hague, The Netherlands.

HsN-projects 4F96.04, 5F97.39, 7F99.47

'Intracellulaire routing en metabolisme van Amyloid Precursor Protein (APP) en de relatie tot de ziekte van Alzheimer'

1997, 1998, 2000

130 kf
International Society for Alzheimers Research (ISAO), Hoofddorp, The Netherlands.

ISAO-project 00506

‘Frameshi­ft mutations, neuronal cell physiology and Alzheimer’

2001-2004

1 PhD-student
Netherlands Organization for Scientific Research (NWO), Section Earth and Life Sciences, Stichting Aard- en Levenswe­tenschappen (ALW), The Hague, The Netherlands.

NWO-ALW-project 811.38.002

‘The role of p24 proteins in prohormone transport through ­the secreto­ry pathway of neuroen­docrine cells’

2002-2005

1 PhD student
Faculty of Science, University of Nijmegen, The Netherlands.

University Research Innovation Project ­400410­

Xenopus transgenes­is for functional neurogenomic­s’

2002-2004

1 post-doc
IOP-Genomics, Senter, The Hague, The Netherlands.

IOP-project IGE01010B

‘Funtional genomics in Xenopu­s: a new perspective for medical research’ (together with Dr. O. Destree / Prof. Dr. A.J.M. Durston, Utrecht and Prof. Dr. B.Oostra / Prof. Dr. F. Grosveld, Rotterdam).

2002-2005

4 post-docs
Organon Laboratories Ltd, Newhouse, Scotland, United Kingdom.

Organon project FN6842

‘The molecular basis of the APO-SUS/UNSUS rat model for schizophrenia’

2002-2003

1 technician
BioPartner (NWO-ALW; ‘Zaaiprojecten’ Life Sciences)

Project 807.03.211

‘Xenogene Solutions: Xenopus transgenesis as a platform for Functional Neurogenomics’

2003


1 post-doc
Synthon B.V., Nijmegen, The Netherlands

Synthon project FN7308

‘Genetic risk factors for schizophrenia’

2006


1 PhD student; 1 technician
TI Pharma, Leiden, The Netherlands

Project T5-209 (G.J.M. Martens, Principal Investigator/Coordinator)

Novel susceptibility pathways and drug targets for psychosis (together with University Leiden UMC and H. Lundbeck A/S, Valby, Denmark)

May 2007- Dec 2013 (total grant: 4 Meuro)

Nijmegen: 2 post-docs, 1 PhD student; 2 technicians; 2 Meuro
Project Donders Center for Neuroscience

Project 62000747 (J. Homberg, A. Kiliaan, G.J.M. Martens)The psychiatrist’s emergency call: What are the long-term effects of Prozac on fetal neurodevelopment?” Departments of Cognitive Neuroscience, Anatomy, Molecular Animal Physiology (Radboud University Nijmegen)

February 2009- May 2010

1 post-doc; Jocelien Olivier (1 year, 2 months); 100 keuro


TI Pharma, Leiden, The Netherlands

Project T5-209 extension (G.J.M. Martens, Principal Investigator/Coordinator)

Novel susceptibility pathways and drug targets for psychosis (together with University Leiden UMC and H. Lundbeck A/S, Valby, Denmark)

May 2009- Dec 2013 (total grant: 1.3 Meuro)

Nijmegen: 1 post-doc, 1 PhD student; 875 keuro
Project Donders Center for Neuroscience

Project 62000888 (S. Kolk, G.J.M. Martens) “Making up your mind: developmental control of cortical parcellation” Department of Molecular Animal Physiology (Radboud University Nijmegen)

October 2009- May 2012

1 post-doc; 180 keuro


Project Donders Center for Neuroscience

Project 62000889 (G.J.M. Martens, A. Valles) “Multi-faceted effects of BDNF I and IV splice variants” Department of Molecular Animal Physiology (Radboud University Nijmegen)

October 2009- April 2012

1 post-doc; 180 keuro


Project Donders Center for Neuroscience

Project UMC (S. Armaz Aschrafi, G.J.M. Martens, T. Heskes, Tj. Dijkstra) “How mitochondria fuel synaptic development and plasticity” Departments of Cognitive Neuroscience (Molecular Neurobiology) and Molecular Animal Physiology (Radboud University Nijmegen)

March 2010-March 2014

1 PhD student; 286 keuro


Stichting Internationaal Parkinson Fonds (Hoofddorp)

Project IPF, 62001277 (J.E. Visser, G.J.M. Martens) “Understanding adaptive neuroplasticity in Parkinson's disease”; Departments of Molecular Animal Physiology (Radboud University Nijmegen) and Neurology (UMC).

March 2011-March 2015

1 PhD student (286 keuro)


EU FP7 framework Program EURenOMICS

Research Project into the (genetic and other) aetiology of rare congenital renal disorders; Nijmegen/Utrecht/Heidelberg total grant: € 12,000,000; 2012-2017.

January 2013-January 2014.

Advisor fee: ~25 keuro


EU FP7 framework Program OPTIMISTIC

Research Project into the (genetic and other) aetiology of myotonic dystrophy (main applicant: Dr. G. Glennon); total grant: € 3,000,000; Nijmegen; 2012-2017.

November 2012-November 2013.

Postdoctoral researcher (30 keuro, 40%)





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