Curriculum vitae family name : Martens



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PATENTS





  1. Protein 7B2 and recombinant DNA and cDNA, mRNA, and antibody for 7B2 and protocol for detection of 7B2; patent number 87.02590, Stichting Katholieke Univer­si­teit Nijmegen; The Netherlands, 30 October 1987; Europe, Japan, USA (patent number 07/263,885; 88.202395.5), 28 October 1988; inventor: G.J.M. Martens.

  2. 7B2 chaperonin - Production of bioactive peptides with recombinant cells; patent number 91.02009, Stichting Katholieke Universiteit Nijmegen; The Netherlands, 29 November 1991; inventor: G.J.M. Martens.

  3. Protein 7B2 as enzyme inhibitor; patent number 94.00032, Stichting Katholieke Universite­it Nijmegen; The Netherlands, 7 January 1994; inventor: G.J.M. Martens.

  4. Protocol to express a coding sequence; patent number 02.45215 (NL 101997), Multi-gen BV/Stichti­ng Katholie­ke Universite­it Nijmegen; The Netherlands, 18 February 2002; inventor: G.J.M. Martens.

  5. Genetic risk factor for neurodevelopmental disorders; international patent number 2005-009852, Synthon BV/Stichti­ng Katholie­ke Universite­it Nijmegen; The Netherlands, 21 September 2005; inventor: G.J.M. Martens.

  6. Drug discovery for neurodevelopmental disorders; international patent number 2005-009853, Synthon BV/Stichti­ng Katholie­ke Universite­it Nijmegen; The Netherlands, 9 September 2005; inventor: G.J.M. Martens.

  7. Genetic risk factor for neurodevelopmental disorders and their complications, in particular epilepsy; international patent number 2005-009854, Synthon BV/Stichti­ng Katholie­ke Universite­it Nijmegen; The Netherlands, 5 December 2005; inventor: G.J.M. Martens.

  8. Animal model suitable for testing drugs and treatments for neurodevelopmental disorders in humans. International patent number 2005-009855, Synthon BV/Stichti­ng Katholie­ke Universite­it Nijmegen; The Netherlands, 22 December 2005; inventor: G.J.M. Martens.

  9. Drug discovery for cancer. International patent number 2006-011266; Synthon BV/Stichti­ng Katholie­ke Universite­it Nijmegen; The Netherlands, 15 December 2006; inventors: K.M.J. van Loo and G.J.M. Martens.

  10. Use of an animal model and method for testing drugs and treatments for cancer in humans. International patent number 2006-011267; Synthon BV/Stichti­ng Katholie­ke Universite­it Nijmegen; The Netherlands, 15 December 2006; inventors: K.M.J. van Loo and G.J.M. Martens.

  11. Genetic risk factor for cancer. International patent number 2006-011265; Synthon BV/Stichti­ng Katholie­ke Universite­it Nijmegen; The Netherlands, 15 December 2006; inventors: K.M.J. van Loo and G.J.M. Martens.

  12. Gene variants in neurodevelopmental and neurodegenerative disorders. Danish priority application (filing No. PA200800228) and as a US provisional (US 61/029782); H. Lunbeck A/S (Copenhagen, Denmark)/Stichti­ng Katholie­ke Universite­it Nijmegen; The Netherlands, 29 February 2008; inventors: G.J.M. Martens et al.


SUPERVISORY FUNCTIONS (thesis advisor - “promotor” - of PhD research projects)
1. T.A.Y. Ayoubi Project: Expression of proopiomelanocortin and the neuroendocrine polypeptide 7B2 in Xenopus pituitary

Period: April 1987-April 1991

Thesis: Regulation of proopiomelanocortin and 7B2 gene expression in the pituitary of Xenopus laevis (9 December 1991)
2. P.M.T. Deen Project: Cloning and structural analysis of the Xenopus proopiomelano­cortin gene

Period: August 1987-August 1991

Thesis: The proopiomelanocortin gene of Xenopus laevis (14 January 1992)
3. D.P.V. De Kleijn Project: The hyperglyce­mic neuro­hormone family in Crustaceans

Period: November 1990- November 1994

Thesis: Cloning, sequence analysis and expression of the hyperglyce­mic neuro­hormone family in Crustaceans (19 May 1995)
4. J.A.M. Braks Project: The role of the neuroendocrine polypeptide 7B2

Period: July 1990-July 1994

Thesis: The role of the neuroendocrine polypeptide 7B2, a molecular chaperone for prohormone convertase PC2 in the secretory pathway (7 November 1995)
5. J.C.M. Holthuis Project: Molecular dissection of the regulated secretory pathway in Xenopus intermediate pituitary

Period: May 1991-May 1995

Thesis: The secretory pathway in peptide hormone-producing cells (21 November 1996)
6. D.W. Eib Project: Cloning, expression and functional studies on a novel TGFa-EGF-like growth factor

Period: February 1992-February 1996

Thesis: Cloning, sequence analysis and expression of 7365, a novel mosaic protein with EGF and follistatin modules (17 June 1998)
7. A.M. van Horssen Project: Functional studies on the novel molecular chaperone 7B2 and its physiological target PC2

Period: August 1993-August 1997

Thesis: Granins in the secretory pathway of peptide hormone-producing cells (24 November 1998)
8. T.M. Holling Project: Development of the pars intermedia in Xenopus laevis.

Period: January 1995-1999.

Thesis: Developmental expression of hypothalamic-pituitary proteins (13 November 2000)
9. W.H. Van den HurkProject: Genomic instability (frame-shift mutations) and Alzhei­mers disease

Period: August 1995-1999

Thesis: Molecular and cell biological aspects of Alzheimer=s β-amyloid precursor and related proteins (2 April 2001)
10. S.W.J. Janssen Project: Hyperglyce­mia-induced dysfunc­tion of the secretory pathway in β-cells as a cause of impaired insulin secretion in NIDD­M (together with Prof. Dr. A.R.M.M. Hermus, Nijmegen)

Period: May 1996- December 2000

Thesis: Cell biological and metabolic aspects of type 2 diabetes mellitus in Zucker diabetic fatty rats, maandag (22 October 2001)
11. R.P. Kuiper Project: Molecular mechanism of prohormone convertase regula­ti­on by the neu­roen­docrine chaperone 7B2

Period: September 1995- September 1999

Thesis: The p24 family of putative cargo receptors in the early secretory pathway of a prohormone-producing cell (31 October 2001)
12. V. SchoonderwoertProject: Modulation of the microenvi­ronment in the TGN/secre­tory granule: the role of a novel accessory subunit of vacuolar H+-ATPa­se

Period: April 1996-April 2000

Thesis: The vacuolar H+-ATPase accessory subunit Ac45 and acidificat­ion in the secretory pathway (28 February 2002)
13. G. Bouw Project: The role of p24 proteins in prohormone transport through ­the secreto­ry pathway of neuroen­docrine cells

Period: January 1998-January 2003

Thesis: A cell-specific transgenic approach in Xenopus

intermediate pituitary: the role of p24 in the early secretory pathway (2 April 2004)


14. R.W.J. Collin Project: The role of APP and APP-like proteins

Period: October 2000 - March 2005

Thesis: Exploring the role of Alzheimer’s amyloid-beta precursor protein APP and its relative APLP2 in Xenopus intermediate pituitary (21 April 2006)
15. M.W. Coolen Project: The molecular basis of a rat model for neurodevelopmental disorders such as schizophrenia.

Period: October 1998 - April 2005

Thesis: Molecular understanding of a rat model with schizophrenia-related features: gene-dosage imbalance of the γ-secretase component Aph-1b in APO-SUS and -UNSUS rats”; Promotores: Prof. dr G.J.M. Martens and Prof. Dr. A.R. Cools; Co-promotor: Dr. B.A. Ellenbroek. (22 December 2006)
16. D.M. De Groot Project: The role of BDNF and neuroserpin in Xenopus intermediate pituitary.

Period: February 2002 – August 2006

Thesis: Neuroseprin and brain-derived neurotrophic factor in neuroendocrine and neuronal plasticity; functional studies in (transgenic) Xenopus intermediate pituitary cells (19 January 2007)
17. J.W.G. van Rosmalen Project: The role of prion protein in Xenopus intermediate pituitary.

Period: September 2000 - April 2005

Thesis: Cell-biological aspects of the prion protein in transgenic Xenopus intermediate pituitary cells (16 February 2007)
18. - Drs. K.M.J. Van Loo; title thesis: “From -secretase in the APO-SUS/-UNSUS rat model to translational research in complex human disorders”; Promotor: Prof. dr G.J.M. Martens, Thesis defense: 9 Janaury 2009, 12.00
19. Ir. J.R.P.M. Strating; title thesis: “The role of the p24 family in ER-to-Golgi protein transport: functional studies using transgenic Xenopus intermediate pituitary cells”; Promotor: Prof. dr G.J.M. Martens Thesis defense: 26 March 2009, 15.30.
20. Ir. J.E. van Schijndel, title thesis: "Towards candidate genes for schizophrenia –

the APO/SUS-APO/UNSUS rat model and human association studies"; Promotor: Prof. dr G.J.M. Martens; Thesis defense: 17 December 2010, 13.00


21. Ing. E.J.R. Jansen; title thesis: “New insights into V-ATPase functioning: the role

of its accessory subunit Ac45 and a novel brain-specific Ac45 paralog”; Promotor: Prof. dr G.J.M. Martens; Thesis defense: 19 December 2011


22. V.D. Eijsink, MSc Cognitive Neuroscience (September 2008 – September 2012);

Promotor: Prof. dr G.J.M. Martens; copromotoresd: Dr. S.M. Kolk/ Dr. G.Poelmans; Thesis defense: end 2013


23. R.W.M. van Vugt, MSc Molecular Mechanisms of Disease – Molecular Life Sciences (April 2009 - April 2013); Promotor: Prof. dr G.J.M. Martens; Thesis defense: end 2013
24. A. Kos, MSc Medical Biology (December 2010-December 2014) Promotor: Prof. dr G.J.M. Martens; copromotor: Dr. A. Aschrafi.
25. Koen Klemann- C.J.H.M. Klemann, MSc Molecular Life Sciences (October 2011-October 2015); Promotores: Prof. dr G.J.M. Martens/ Prof B. Bloem; copromotores: Dr. J. Visser/Dr. G.Poelmans.

TEACHING


  • Bachelor course Developmental Physiology (students Biology, Medical Biology, Molecular Life Sciences; total course: 6 ECTS; G. Martens: 4 ECTS) (1994-present; BFCA-BB039B-9A/9B)

  • Master Course capita selecta Molecular and Cellular Neurobiology (students Biology, Medical Biology, Molecular Life Sciences and Master students Cognitive Neuroscience; total course: 3 ECTS; G. Martens: 1.5 ECTS) (1998-present; BFCA-BM001C-9A)

  • Master Enrichment Course Advanced Molecular and Cellular Neurobiology (Master students Cognitive Neuroscience; total course: 3 ECTS; G. Martens: 3 ECTS) (2005-present; SOCW-CNNC03A-01)

  • Master course Molecular Neurobiology, Track Tissue Reconstruction, Technical Medicine, University Twente, Enschede (total course: 5 ECTS; G. Martens: 5 ECTS) (2006-2008)

  • Lectures NCMLS Graduate Course (2003-present); Lectures NCMLS Master Course Molecular Mechanisms of Disease (2005-present); Lectures Master courses outside Nijmegen (VU Amsterdam; U Utrecht)

  • Supervising internships and literature theses of Bachelor and Master students Biology, Medical Biology, Molecular Life Sciences, Cognitive Neuroscience, Biomedical Sciences and Applied Sciences (HLO) (1980-present)

  • Director of Education in Molecular Life Sciences, Faculty of Science, Radboud University, Nijmegen (2008-present)

  • Local coordinator and lecturer during the two-week LLP Erasmus Intensive Program “CLASSIC AND MODERN METHODS FOR MOLECULAR DIAGNOSTICS IN HUMAN PATHOLOGY” in Brasov, Romania (EU project 11-EIP-RO BRASOV 01, coordinated by Mrs. Antonella Chesca, MD PhD, Transilvania University of Brasov, Romania).


SELECTION OF PUBLICATIONS

(from a total of 186 publications in international scientific journals; see below for complete list)




  • Martens, G.J.M., Jenks, B.G. and Van Overbeeke, A.P. (1981) Nα-acetylation is linked to α-MSH release from pars intermedia of the amphibian pituitary gland. Nature 294, 559-560. (IF 36.3)

  • Martens, G.J.M. and Herbert, E. (1984) Polymorphism and absence of leu-enkepha­lin sequences in proenkephalin genes in Xenopus laevis. Nature 310, 251-254. (IF 36.3)

  • Martens, G.J.M., Braks, J.A.M., Eib, D.W., Zhou, Y. and Lindberg, I. (1994) The neuroen­docrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2. Proc. Natl. Acad. Sci. USA 91, 5784-5787. (IF 9.7)

  • Braks, J.A.M. and Martens, G.J.M. (1994) 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway. Cell 78, 263-273. (IF 32.4)

  • Van Leeuwen, F.W., De Kleijn, D.P.V., Van den Hurk, H.H., Neubauer, A., Sonnemans, M.A.F., Sluijs, J.A., Köycü, S., Ramdjielal, Salehi, A., Martens, G.J.M., Grosveld, F., Burbach, J.P.H. & Hol, E.M. (1998) Frameshift mutants of β-amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. Science 279, 242-247. (IF 31.2)

  • Tooze, S.A., Martens, G.J.M. & Huttner, W.B. (2001) Secretory granule biogenesis: rafting to the SNARE. Trends in Cell Biol. 11, 116-122. (IF 12.4)

  • Serneels, L., Dejaegere, T., Craessaerts, K., Horré, K., Jorissen, E., Tousseyn, T., Hébert, S., Coolen, M., Martens, G., Zwijsen, A., Annaert, W., Hartmann, D. & De Strooper, B. (2005) Differential contribution of the three Aph1 proteins to -secretase activity in vivo. Proc. Natl. Acad. Sci. USA 102,1719-1724. (IF 9.7)

  • Coolen, M.W., Van Loo, K.M.J., Van Bakel, N.N.H.M., Pulford, D.J., Serneels, L., De Strooper, B., Ellenbroek, B.A., Cools, A.R. & Martens, G.J.M. (2005) Gene-dosage effect on γ-secretase component Aph-1b in a rat model for neurodevelopmental disorders. Neuron 45, 497-503. (IF 14.8)

  • Coolen, M.W., Van Loo, K.M.J., B., Ellenbroek, B.A., Cools, A.R. & Martens, G.J.M. (2006) Ontogenic reduction of Aph-1b mRNA and gamma-secretase activity in rats with a complex neurodevelopmental phenotype. Mol. Psychiatry 11, 787-793 (with cover figure of study). (IF15.5)

  • Marshak, S., Nikolakopoulou,A.M., Dirks, R.P., Martens, G.J.M. and Cohen-Cory, S. (2007) Cell autonomous TrkB signalling in presynaptic retinal ganglion cells mediates axon arbor growth and synapse maturation during the establishment of retinotectal synaptic connectivity. J. Neuroscience 27, 2444-2456. (IF 7.1)

  • Strating, J.R.P.M., Van Bakel, N.H.M., Leunissen, J.A.M. and Martens, G.J.M. (2009) A comprehensive overview of the vertebrate p24 family: identification of a novel tissue-specifically expressed member. Molecular Biology and Evolution, 26, 1707-1714. (IF 5.6)

  • Jansen, Eric J.R., Nick H.M. van Bakel, Anthon J.M. Coenen, Sander H. van Dooren, Hermina A.M. van Lith and Gerard J.M. Martens (2010) An isoform of the vacuolar (H+)-ATPase accessory subunit Ac45. Cellular and Molecular Life Sciences 67, 629-640. (IF 6.6)

  • Vallès, A., Boender, A.J., Gijsbers S., Haast, R.A.M., Martens, G.J.M* and de Weerd, P.* (2011) Genome-wide analysis of rat barrel cortex reveals time- and layer-specific mRNA expression changes related to experience-dependent plasticity. J. Neuroscience 31, 6140-6158. * equal contribution. (IF 7.1)

  • Jansen E.J.R., Nick. H.M. van Bakel, Nikkie F.M. Olde Loohuis, Theo G.M. Hafmans, Tim Arentsen, Anthon J.M. Coenen, Wim J.J.M. Scheenen and Martens, G.J.M. (2012) Identification of domains within the V-ATPase accessory subunit Ac45 involved in V-ATPase transport and Ca2+-dependent exocytosis. J Biol. Chem. 287:27537-27546. (IF 5.3)



COMPLETE LIST OF PUBLICATIONS
1. Van Haard, P.M.M., Martens, G.J.M., Mestrom, J.J.L., Hoenders, H.J. & Wollen­sak, J. (1979) Very acidic polypeptide chains from old human eye lenses. Ophthal­mic Res. 11, 433-440.
2. Martens, G.J.M., Jenks, B.G. & van Overbeeke, A.P. (1980) Analysis of peptide biosyn­thesis in the neurointermediate lobe of Xenopus laevis using high-perfor­mance liquid chromatography: occurrence of small bioactive peptides. Comp. Biochem. Physiol. 67B, 493-497.
3. Martens, G.J.M., Jenks, B.G. & van Overbeeke, A.P. (1981) Microsuperfusion of neurointer­mediate lobes of Xenopus laevis: concomitant and coordinately controlled release of newly synthesized peptides. Comp. Biochem. Physiol. 69C, 75-82.
4. Martens, G.J.M., Jenks, B.G. & van Overbeeke, A.P. (1981) N-acetylation is linked to -MSH release from pars intermedia of the amphibian pituitary gland. Nature 294, 559-560.
5. Martens, G.J.M., Jenks, B.G. & van Overbeeke, A.P. (1982) Biosynthesis of pairs of peptides related to melanotropin, corticotropin and endorphin in the pars intermedia of the amphibian pituitary gland. Eur. J. Biochem. 122, 1-10.
6. Martens, G.J.M., Biermans, P.-P.J., Jenks, B.G. & van Overbeeke, A.P. (1982) Biosyn­thesis of two structurally different pro-opiomelanocortins in the pars intermedia of the amphibian pituitary gland. Eur. J. Biochem. 126, 17-22.
7. Martens, G.J.M., Jenks, B.G. & van Overbeeke, A.P. (1982) Biosynthesis of a 3-melanotropin-like peptide in the pars intermedia of the amphibian pituitary gland. Eur. J. Biochem. 126, 23-28.
8. Martens, G.J.M., Soeterik, F., Jenks, B.G. & van Overbeeke, A.P. (1983) In vivo biosyn­thesis of melanotropins and related peptides in the pars intermedia of Xenopus laevis. Gen. Comp. En­docrinol. 49, 73-80.
9. Jenks, B.G., van Daal, J.H.H.N., Scharenberg, J.G.M., Martens, G.J.M. & van Over­beeke, A.P. (1983) Biosynthesis of pro-opiomelanocortin-derived peptides in the mouse neurointer­mediate lobe. J. Endocrinol. 98, 19-34.
10. Jenks, B.G., Cruijsen, P.M.J.M., Feyen, J.H.M., Martens, G.J.M. & van Over­beeke, A.P. (1983) Effects of tunicamycin on biosynthesis of pars intermedia peptides in the mouse. In: Neuropeptides and Psychosomatic Processes. Endroczi et al., eds., Academiai Kiado, Budapest, pp. 281-287.
11. Civelli, O., Oates, E., Rosen, H., Martens, G.J.M., Douglass, J. & Herbert, E. (1983) Expression of the opioid genes. In: Biochemical and Clinical Aspects of Neuropepti­des: Synthesis, Processing and Gene Structure. Koch, G. & Richter, D., eds., Acade­mic Press: New York, pp. 45-57.
12. Herbert, E., Oates, E., Martens, G.J.M., Comb, M., Rosen, H. & Uhler, M. (1983) Generation of diversity and evolution of opioid peptides. In Cold Spring Harbor Symposia on Quantitative Biology, Vol. 48, Molecular Neurobiology, Cold Spring Harbor Laboratory, New York, pp. 375-384.
13. Martens, G.J.M. & Herbert, E. (1984) Polymorphism and absence of leu-enkepha­lin sequences in proenkephalin genes in Xenopus laevis. Nature 310, 251-254.
14. Herbert, E., Comb, M., Rosen, H. & Martens, G.J.M. (1984) Expression of opioid genes in different species. In: Cellular and Molecular Biology of Neuronal Development. Black, I.B., ed. pp. 279-292.
15. Martens, G.J.M., Civelli, O. & Herbert, E. (1985) Nucleotide sequence of cloned cDNA for proopiomelanocortin in the amphibian Xenopus laevis. J. Biol. Chem. 260, 13685-13689.
16. Jenks, B.G., Martens, G.J.M., van Helden, H.P.M. & van Overbeeke (1985) Biosyn­thesis and release of melanotropins and related peptides by the pars inter­media of Xenopus laevis. In: Current Trends in Comparative Endocrinology. Lofts, B. & Holmes, W.N., Eds. Hong Kong, Hong Kong University Press, pp. 149-153.
17. Herbert, E., Civelli, O., Douglass, J., Martens, G. & Rosen, H. (1985) Generation of diversity of opioid peptides. In: Biochemical Actions of Hormones. Litwack, G., ed. Academic Press vol. 12, pp. 1-36.
18. Martens, G.J.M., Civelli, O. & Herbert, E. (1986) Opioid peptide precursors in the am­phibian Xenopus laevis. In: Role of RNA and DNA in Brain Function - a molecu­lar biological approach. Giuditta, A., Kaplan, B.B. & Zomzely Nuerath, C., eds., Nijhoff, M., Boston, pp. 299-302.
19. Civelli, O., Douglass, J., Rosen, H. Martens, G. & Herbert, E. (1986) Biosynthesis of opioid peptides. In: National Institute of Drug Abuse Research Monograph, vol. 70, pp. 21-42.
20. Martens, G.J.M., (1986) Expression of two proopiomelanocortin genes in the pituitary gland of Xenopus laevis: complete structures of the two preprohormones. Nucleic Acids Res. 14, 3791-3798.
21. Martens, G.J.M., Weterings, K.A.P., van Zoest, I.D. & Jenks, B.G. (1987) Physiological­ly-induced changes in proopiomelanocortin mRNA levels in the pituitary gland of the amphibian Xenopus laevis. Biochem. Biophys. Res. Commun. 143, 678-684.
22. Martens, G.J.M. (1987) Structural organization of the proopiomelanocortin gene in Xenopus laevis: 5' end homologies within the toad and mammalian genes. Eur. J. Biochem. 165, 467-472.
23. Martens, G.J.M. (1988) The proopiomelanocortin gene in Xenopus laevis: structure, expression and evolutionary aspects. In: The melanotropic peptides. Hadley, M.E., ed., CRC Press, vol. 1, ch. 6, pp. 67-83.
24. Jenks, B.G., Verburg-van Kemenade, B.M.L. & Martens, G.J.M. (1988) Proopiomelanocortin in the amphibian pars intermedia: a neuroendocrine model system. In: The melanotropic peptides. Hadley, M.E., ed., CRC Press, vol. 1, ch. 8, pp. 103-125.
25. Martens, G.J.M. (1988) Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2. FEBS Letters 234, 160-164.
26. Martens, G.J.M., Bussemakers, M.J.G., Ayoubi, T.A.Y. & Jenks, B.G. (1989) The novel pituitary polypetide 7B2 is a highly-conserved protein coexpressed with proopiomelanocortin. Eur. J. Biochem. 81, 75-79.
27. Roebroek, A.J.M., Dehaen, M.R.M., van Bokhoven, A., Martens, G.J.M., Marij­nen, P., van den Berghe, H. & van de Ven, W.J.M. (1989) Regional mapping of the gene encoding the novel pituitary polypeptide 7B2 to human chromosome 15q13-q14 by in situ hybridization. Cytogenet. Cell Genet. 50, 158-160.
28. Roebroek, A.J.M., Martens, G.J.M., Duits, A.J., Schalken, J.A., van Bokhoven, A., Wagenaar, S.Sc. & van de Ven, W.J.M. (1989) Differential expression of the gene encoding the novel pituitary polypeptide 7B2 in human lung cancer cells. Cancer Res. 49, 4154-4158.
29. Van Duijnhoven, H.L.P., Ayoubi, T.A.Y., Timmer, E.D.J., Braks, J.A.M., Roe­broek, A.J.M., Martens, G.J.M. & van de Ven, W.J.M. (1989) Development of a monoclo­nal antibody against recombinant neuroen­docrine 7B2 protein. FEBS Lett. 255, 372-376.
30. Martens, G.J.M., Groenen, P.J.T.A., Braks, J.A.M. & Bussemakers, M.J.G. (1989) Expres­sion of two growth hormone genes in the Xenopus pituitary gland. Nucleic Acids Res. 17, 3974.
31. Ayoubi, T.A.Y., van Duijnhoven, H.L.P., van de Ven, W.J.M., Jenks, B.G., Roubos, E.W. & Martens, G.J.M. (1990) The neuroendocrine polypeptide 7B2 is a precursor protein. J. Biol. Chem. 265, 15644-15647.
32. Ayoubi, T.A.Y., van Duijnhoven, H.L.P., Coenen, A.J.M., Jenks, B.G., Roubos, E.W. & Martens, G.J.M. (1991) Coordinated expression of 7B2 and -MSH in the melanotrope cells of Xenopus laevis: an immunocytochemical and in situ hybridizati­on study. Cell Tissue Res. 264, 329-334.
33. Martens, G.J.M., Molhuizen, H.O.F., Gröneveld, D. & Roubos, E.W. (1991) Cloning and sequence analysis of brain cDNA encoding a Xenopus D2 dopamine receptor. FEBS Lett. 281, 85-89.
34. Ayoubi, T.A.Y., de Kleijn, D.P.V., Roubos, E.W. & Martens G.J.M. (1991) A method for the analysis of newly synthesized mRNA. Nucleic Acids Res. 19, 3751.
35. Deen, P.M.T., Terwel, D., Bussemakers, M.J.G., Roubos, E.W. & Martens, G.J.M. (1991) Structural analysis of the entire proopiomelanocortin gene B of Xenopus laevis. Eur. J. Biochem. 201, 129-137.
36. Deen, P.M.T., Roubos, E.W. & Martens, G.J.M. (1991) Presence of Vi-transpo­son-like elements in Xenopus laevis proopiomelanocortin gene A does not affect gene activity. Mol. Gen. Gen. 230, 491-493.
37. Van Riel, M.C.H.M. & Martens, G.J.M. (1991) Cloning and sequence analysis of pituitary cDNA encoding the -subunit of Xenopus proteasome. FEBS Lett. 291, 37-40.
38. Deen, P.M.T., Bussemakers, M.J.G., Ter­wel, D., Roubos, E.W. & Martens, G.J.M. (1992) Comparative structural analysis of the transcriptionally active proopiomelanocortin genes A and B of Xenopus laevis. Mol. Biol. and Evol. 9, 483-494.
39. Martens, G.J.M. (1992) Molecular biology of G-protein-coupled recep­tors. In: 'The Peptidergic Neuron' (J. Joosse & R.M. Buijs, eds.) Progr. in Brain Res. 92, pp. 201-214 (Chapter 17), Elsevier Publ. Co., Amsterdam.
40. Ayoubi, T.A.Y., Jenks, B.G., Roubos, E.W. & G.J.M. Martens (1992) Transcrip­tional and posttranscriptional regulation of the proopiomelanocortin gene in the pars intermedia of the pituitary gland of Xenopus laevis. Endocrinology 130, 3560-3566.
41. Martens, G.J.M., Piosik, P.A. & Danen, E.H.J. (1992) Evolutionary conservation of the 14-3-3 protein. Biochem. Biophys. Res. Commun. 184, 1456-1459.
42. Braks, J.A.M., Guldemond, K.C.W., van Riel, M.C.H.M., Coenen, A.J.M. & Mar­tens, G.J.M. (1992) Structure and expression of Xenopus prohormone convertase PC2. FEBS Lett. 305, 45-50.
43. Jenks, B.G., Leenders, H.J., Martens, G.J.M. & Roubos, E.W. (1993) Adaptation Physiology: the functioning of pituitary melanotrope cells during background adaptation of the amphibian Xenopus laevis. Zool. Sci. 10, 1-11.
44. Van Riel, M.C.H.M., Tuinhof, R., Roubos, E.W. & Martens, G.J.M. (1993) Cloning and sequence analysis of hypothalamic cDNA encoding Xenopus prepron­europeptide Y. Biochem. Biophys. Res. Commun. 190, 948-951.
45. Heideveld, M., Ayoubi, T.A.Y., van de Wiel, M.H.J., Martens, G.J.M. & Durston, A.J. (1993) Proopiomelanocrotin gene expression as a neural marker during the embryonic development of Xenopus laevis. Differentiation 52, 195-200.
46. Goverde, H.J.M., Martens, G.J.M., Pesman, G.J. & Smals, A.G.H. (1993) Mutiple forms of bioactive and immunoreactive adrenocorticotropin in human pituitary and blood of patients with Nelson's syndrome. J. Clin. Endocrinol. Metab. 77, 443-447.
47. Roubos, E.W., Martens, G.J.M. & Jenks, B.G. (1993) Control of melanotrope cell activity in Xenopus laevis. Ann. N.Y. Acad. Sci. 680, 130-134.
48. Martens, G.J.M., Groenen, P.M.A., Gröneveld, D. & van Riel, M.C.H.M. (1993) Expression of the Xenopus D2 dopamine receptor: Tissue-specific regulation and two transcriptionally active genes but no evidence for alternative splicing. Eur. J. Bi­ochem. 213, 1349-1354.
49. Gröneveld, D., Hut, M.J., Balm, P.H.M., Martens, G.J.M. & Wendelaar Bonga, S.E. (1993) Cloning and sequence analysis of hypothalamic cDNA encoding tilapia melanin-concentrating hormone. Fish Physiol. Biochem. 11, 117-124.
50. Roth, D., Morgan, A., Martin, H., Jones, D., Martens, G.J.M., Aitken, A. & Burgoy­ne, R.D. (1994) Characterization of 14-3-3 proteins in adrenal chromaffin cells and demonstration of isoform-specific phospholipid binding. Biochem. J. 301, 305-310.
51. Holthuis, J.C.M., Schoonderwoert, V.T.G. & Martens, G.J.M. (1994) A vertebrate homolog of the actin-bundling protein fascin. Biochim. Biophys. Acta 1219, 184-188
52. De Kleijn, D.P.V., Sleutels, F.J.G.T., Martens, G.J.M. & Van Herp, F. (1994) Cloning and expression of mRNA encoding prepro-Gonad-Inhibiting Hormone (GIH) in the Lobster Homarus americanes. FEBS Letters 353, 255-258.
53. De Kleijn, D.P.V., Janssen, K.P.C., Martens, G.J.M. & Van Herp, F. (1994) Cloning and expression of two crustacean hyperglycemic-hormone mRNAs in the eyestalk of the crayfish Orconectus limosus. Eur. J. Biochem. 224, 623-629.
54. Martens, G.J.M., Braks, J.A.M., Eib, D.W., Zhou, Y. & Lindberg, I. (1994) The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone converta­se PC2. Proc. Natl. Acad. Sci. USA 91, 5784-5787.
55. Braks, J.A.M. & Martens, G.J.M. (1994) 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase in the secretory pathway. Cell 78, 263-273.
56. Gabreëls, B.A.Th.F., Swaab, D.F., Seidah, N.G., Van Duijnhoven, H.L.P., Mar­tens, G.J.M. & Van Leeuwen, F.W. (1994) Differential expression of the neuroen­docrine polypeptide 7B2 in hypothalami of Prader-(Labhart)-Willi syndrome patients. Brain Research 657: 281-293.
57. De Kleijn, D.P.V., De Leeuw, E.P.H., Van den Berg, M.C., Martens, G.J.M. & Van Herp, F. (1995) Cloning and expression of two mRNAs encoding structurally different Crustacean Hyperglycemic Hormone precursors in the Lobster Homarus americanes. Biochim. Biophys. Acta 1260, 62-66.
58. De Kleijn, D.P.V., Janssen, K.P.C., Lai, W.Y., Hegeman, R., Martens, G.J.M., Waddy, S.L. & Van Herp, F. (1995). 'Expression, storage and release of Crustace­an Hyperglyce­mic Hormones and Gonad Inhibiting Hormone during the reproducti­ve cycle of the female American lobster Homarus americanus', Neth. J. Zool. 45, 238-240.
59. Gröneveld, D., Eckhardt, E.R.M., Coenen, A.J.M., Martens, G.J.M., Balm, P.H.M. & Wendelaar Bonga, S.E. (1995) Expression of tilapia prepro-melanin-concentrating hormone mRNA in hypothalamic and neurohypophysial cells. J. Mol. Endocrinol. 14, 199-207.
60. Gröneveld, D., Balm, P.H.M., Martens, G.J.M. & Wendelaar Bonga, S.E. (1995) Differential melanin-concentrating hormone gene expression in two hypothalamic nuclei of the teleost tilapia in response to environmental changes. J. Neuroendocri­nol. 7, 527-533.
61. Chaudhuri, B., Stephan, C., Huijbregts, R.P.H. & Martens, G.J.M. (1995) The neuroendocrine protein 7B2 acts as a molecular chaperone in the in vitro folding of human insulin-like growth factor-1 secreted from yeast. Biochem. Biophys. Res. Commun. 211, 417-425.
62. Blomqvist, A.G., Roubos, E.W., Larhammar, D. & Martens, G.J.M. (1995) Cloning and sequence analysis of a neuropeptide Y/peptide YY receptor Y1 cDNA from Xenopus laevis. Biochim. Biophys. Acta 1261, 439-441.
63. Van Horssen, A.M., Van den Hurk, W.H., Bailyes, E.M., Hutton, J.C., Martens, G.J.M. & Lindberg, I. (1995) Identification of the region within the neuroendocri­ne polypeptide 7B2 responsible for the inhibition of prohormone convertase PC2. J. Biol. Chem. 270, 14292-14296.
64. Braks, J.A.M. & Martens, G.J.M. (1995) The neuroendocrine chaperone 7B2 can enhance in vitro POMC cleavage by prohormone convertase PC2. FEBS Lett. 371, 154-158.
65. Holthuis, J.C.M., Van Riel, M.C.H.M. & Martens, G.J.M. (1995) Translo­con-associated protein TRAP and a novel TRAP-like protein are coordina­tely expres­sed with proopiome­lanocortin in Xenopus intermediate pituitary. Biochem. J. 312, 205-213.
66. Holthuis, J.C.M., Jansen, E.J.R., Van Riel, M.C.H.M. & Martens, G.J.M. (1995) Molecular probing of the secretory pathway in peptide hormone-producing cells. J. Cell Science 108, 3295-3305.
67. Braks, J.A.M., Broers, C.A.M., Danger, J.-M.H.A. & Martens, G.J.M. (1996) Structural organization of the gene encoding the neuroendocrine chaperone 7B2. Eur. J. Biochem. 236, 60-67.
68. Braks, J.A.M., Van Horssen, A.M. & Martens, G.J.M. (1996). Dissociation of the complex between the neuroendocrine chaperone 7B2 and prohormone convertase PC2 is not associated with proPC2 maturation. Eur. J. Biochem. 238, 505-510.
69. Holthuis, J.C.M. & Martens, G.J.M. (1996) The neuroendocrine proteins secretog­ranin II and -III are regionally conserved and coordinately expressed with proopio­melanocortin in Xenopus intermediate pituitary. J. Neurochem. 66, 2248-2256.
70. Holthuis, J.C.M., Jansen, E.J.R. & Martens, G.J.M. (1996) Secretogranin III is a sulfated precursor protein undergoing proteolytic processing in the regulated secretory pathway. J. Biol. Chem. 271, 17755-17760.
71. Eib, D.W. & Martens, G.J.M. (1996) A novel transmembrane protein with an EGF and two follistatin domains. J. Neurochem. 67, 1047-1055.
72. Lamers, A.E., Gröneveld, D., de Kleijn, D.P.V., Geeraedts, F.C.G., Leunissen, J.A.M., Flik, G., Wendelaar Bonga, S.E. & Martens, G.J.M. (1996) Cloning and sequence analysis of a hypothalamic cDNA encoding a D1c dopamine receptor in tilapia. Biochim. Biophys. Acta 1308, 17-22.
73. Martens, G.J.M. (1997) The neuroendocrine polypeptide 7B2. In: M.-J. Gething, ed. Guidebook to Molecular Chaperones and Protein Folding Factors, Section cpn60/cpn­10 proteins. Oxford: Sambrook and Tooze at Oxford University Press. pp. 201-204.
74. Spijker, S., Smit, A.B., Martens, G.J.M. & Geraerts, W.P.M. (1997) Identification of a molluscan homologue of the neuroendocrine polypeptide 7B2. J. Biol. Chem. 272, 4116-4120.
75. Van Kuppeveld, F.J.M., Van Horssen, A.M. & Martens, G.J.M. (1997) Intracel­lular transport, sorting, and proteolytic processing of regulated secretory proteins does not require protein sulfation. Mol. and Cell. Endocrinology 136, 29-35.
76. Van Horssen, A.M. & Martens, G.J.M. (1998) The neuroendocrine polypeptide 7B2 as a molecular chaperone and naturally occurring inhibitor of prohormone converta­se PC2. In: V. Hook, ed. Proteolytic and Cellular Mechanisms in Prohor­mone and Neuro­peptide Precursor Processing. Austin: RG Landes Co., USA, Chapter 8, pp. 141-158.
77. Gabreëls, B.A.Th.F., Swaab, D.F., de Kleijn, D.P.V., Seidah, N.G., Van de Loo, J.-W., Van de Ven, W.J.M., Martens, G.J.M. & Van Leeuwen, F.W. (1998) Attenua­tion of the polypeptide 7B2, prohormone convertase PC2 and vasopressin in the hypothalamus of some Prader-Willi patients: indications for a processing defect. J. Clin. Endocri­nol. Metab. 83, 591-599.
78. Van Horssen, A.M., Van Kuppeveld, F.J.M. & Martens, G.J.M. (1998) The role of disulphi­de bonds in the intracellular transport, sorting and processing of neu­roendocrine secretory proteins. J. Neurochem.71, 402-409.
79. Gabreëls, B., Swaab, D., de Kleijn, D., Dean, A., Seidah, N., Van de Loo, J.-W., Van de Ven, W.J.M., Martens, G.J.M. & Van Leeuwen, F.W. (1998) The vasop­ressin precursor is not processed in the hypothalamus of Wolfram syndrome patients with diabetes insipidus: evidence for the involvement of PC2 and 7B2. J. Clin. Endocrinol. Metab. 83, 4027-4033.
80. De Kleijn, D.P.V., Janssen, K.P.C., Waddy, S.L., Hegeman, R., Lai, W.Y., Martens, G.J.M. & Van Herp, F. (1998) Expression of the crustacean hyperglcaemic hormones and the gonad-inhibiting hormone during the reproductive cycle of the female American lobster Homarus americanus. J. Endocrinology 156, 291-298.


  1. Van Leeuwen, F.W., De Kleijn, D.P.V., Van den Hurk, H.H., Neubauer, A., Sonne­mans, M.A.F., Sluijs, J.A., Köycü, S., Ramdjielal, Salehi, A., Martens, G.J.M., Grosveld, F., Burbach, J.P.H. & Hol, E.M. (1998) Frameshift mutants of -amyloid precursor protein and ubiquitin-B in Alzheimer's and down patients. Science 279, 242-247.




  1. Van Horssen,­ A.M. & Martens, G.J.M. (1998) Mapping of the domain in the neuroendocrine protein 7B2 important for its helper function towards prohormo­ne convertase PC2. Mol. and Cell. Endocrinology 137, 7-12.




  1. Arends, R.J., Van der Gaag, R., Martens, G.J.M., Wendelaar Bonga, S.E. & Flik, G. (1998) Differential expression of two pro-opiomelanocortin mRNAs during tempera­ture stress in common carp (Cyprinus carpio L.) J. Endocrinol. 159, 85-91.




  1. C.H. Dotman, van Herp, F., Martens, G.J.M., Jenks, B.G. & Roubos, E.W. (1998) Dynamics of proopiomelanocortin and prohormone convertase 2 gene expression in Xenopus melanotrope cells during long-term background adaptation. J. Endocrinol. 159, 281-286.




  1. Jansen, E.J.R., Holthuis, J.C.M., McGrouther, C., Burbach, J.P.H. & Martens, G.J.M. (1998) Intracellular trafficking of the vacuolar H+ ATPase accessory subunit Ac45. J. Cell Science 111, 2999-3006.




  1. Arends, R.J., Vermeer, H., Martens, G.J.M., Leunissen, J.A.M., Wendelaar Bonga, S.E. & Flik, G. (1998) Cloning and expression of two proopiomelanocortin mRNAs in the common carp (Cyprinus carpio L.) Mol. and Cell. Endocrinology 143, 23-31.




  1. Eib, D.W., Merkx, G.F.M., Martens, G.J.M. & Cremers, F.P.M. (1998) Assignment of H7365 (C9orf2) to human chromosome band 9q31 by somatic cell hybrid analysis and fluorescence in situ hybridization. Cytogenetics Cell Genet. 81, 180-181.




  1. Van den Hurk, W.H. , Van Leeuwen, F.W. & Martens, G.J.M. (1999) Aging, Alzhei­mer’s disease and frameshift mutations. In: W.E. Crusio and R.T. Gerlai, eds. Handbook of Molecular-Genetic Techniques for Brain and Behavioural Research (Techniques in the Behavioural and Neural Sciences). Elsevier Science B.V. vol. 13, pp. 863-879.




  1. Holthuis, J.C.M., Jansen, E.J.R., Schoonderwoert, V.Th.G., Burbach, J.P.H. & Martens, G.J.M. (1999) Biosynthesis of the vacuolar H+-ATPase accessory subunit Ac45 in Xenopus pituitary. Eur. J. Biochem. 262, 484-491.




  1. Van Horssen,­ A.M. & Martens, G.J.M. (1999) Biosynthesis of secretogranin -II in Xenopus intermediate pituitary. Mol. and ­Cell. Endocrinology 147, 57-64.

91. Martens, G.J.M. (1999) Molecular dissection of the secretory pathway in neuroendo­crine cells. In: E.W. Roubos, S.E. Wendelaar Bonga, H. Vaudry and A. De Loof, eds. Recent Developments in Comparative Endocrinology and Neurobiology.Shaker Publishing B.V. pp. 47-51.


92. Janssen, S.W.J., Martens, G.J.M., Sweep, C.G.J., Ross, H.A. & Hermus, A.R.M.M. (1999) In Zucker diabetic fatty rats plasma leptin levels are correlated with plasma insulin levels rather than with body weight. Horm. Metab. Res. 31, 610-615.


  1. Kuiper, R.P., Rötter, J., Bouw, G., Waterham, H.R. & Martens, G.J.M. (1999) The p24 family of putative cargo receptors in the secretory pathway. In: Recent Developments in Comparative Endocrinology and Neurobiology. (Roubos, E.W., Wedelaar-Bonga, S.E., Vaudry, H., and DeLoof, A., eds), Shaker Publishing, Maastricht. pp. 69-70.




  1. Jongsma, J., Oomen, M., Noordzij, M.A., Van Weerden, W.M., Martens, G.J.M., Van der Kwast, Th.H., Schröder, F.H. & Van Steenbrugge, G.J. (1999) Kinetics of neuroendocrine differentiation in an androgen-dependent human prostate xenograft model. Am. J. Pathol. 154, 543-551.




  1. Van Enckevort, F.H.J., Pepels, P.P.L.M., Leunissen, J.A.M., Martens, G.J.M., Wendelaar Bonga, S.E. & Balm, P.H.M. (2000) Oreochromis mossambicus (Tilapia) corticotropin-releasing hormone: cDNA sequence and bioactivity. J. Neuroendocrinol. 12, 177-186.




  1. Kuiper, R.P., Waterham, H.R., Rötter, J., Bouw, G. & Martens, G.J.M. (2000) Differential induction of two p24 putative cargo receptors upon activation of a prohormone-producing cell. Mol. Biol. Cell 11, 131-140.




  1. Holling, T.M., van Herp, F., Martens, G.J.M. (2000) Induction of proopiomelanocortin mRNA expression in animal caps of Xenopus laevis embryos. Development, Growth & Differentiation, 42, 413-418.




  1. Holling, T.M., van Herp, F., Durston, A.J., Martens, G.J.M. (2000). Differential onset of expression of mRNAs encoding proopiomelanocortin, prohormone convertases 1 and 2, and granin family members during Xenopus laevis development. Molecular Brain Research 75, 70-75.




  1. De Groot, E., Feijen, A., Eib, D., Zwijsen, A., Sugino, H., Martens, G.J.M., van den Eijnden-van Raaij, A. (2000) Expression patterns of follistatin and two follistatin-related proteins in mouse development. Int. J. Dev. Biol. 44, 327-330.




  1. Kuiper, R.P. & Martens, G.J.M. (2000) Prohormone transport through the secretory pathway of neuroendocrine cells. Biochem. Cell Biol. – Biochimie et Biologie Cellulaire. 78, 289-298.




  1. Eib, D.E., Holling, T.M., Zwijsen, A., Dewulf, N., De Groot, E., Van den Eijnden-Van Raaij, A.J.M., Huylebroeck, D. & Martens, G.J.M. (2000) Expression of the follistatin/EGF-containing transmembrane protein M7365 (tomoregulin-1) during mouse development. Mech. Development 79, 167-171.




  1. Jongsma, J., Oomen, M.H., Noordzij, M.A., Van Weerden, W.M., Martens, G.J.M., Van der Kwast, Th.H., Schröder, F.H. & Van Steenbrugge, G.J. (2000) Androgen deprivation of the PC-310 human prostate cancer model system induces neuroendocrine differentiation. Cancer Res. 60, 741-748.




  1. Schoonderwoert, V.Th.G., Holthuis, J.C.M., Tanaka, S., Tooze, S.A. & Martens, G.J.M. (2000). Inhibition of the vacuolar H+ ATPase perturbs the transport, sorting, processing and release of regulated secretory proteins. Eur. J. Biochem. 267, 5646 5654.




  1. Schoonderwoert, V.Th.G. & Martens, G.J.M. (2001) Proton pumping in the secretory pathway. J. Membrane Biol. 182, 159-169.




  1. Van den Hurk, W.H., Willems, H.J.J., Bloemen, M. & Martens, G.J.M. (2001) Novel frameshift mutations near short simple repeats. J. Biol. Chem. 276, 11496-11498.




  1. Tooze, S.A., Martens, G.J.M. & Huttner, W.B. (2001) Secretory granule biogenesis: rafting to the SNARE. Trends in Cell Biol. 11, 116-122.




  1. Morais da Silva, S., Gates, P.B., Eib, D.W., Martens, G.J.M. & Brockes, J.P. (2001) The expression pattern of tomoregulin-1 in urodele limb regeneration and mouse limb development. Mech. Development 104, 125-128.




  1. Janssen, S.W.J., Hermus, A.R.M.M., Lange, W.P.H., Knijnenburg, Q., Van der Laak, J.A.W.M., Sweep, C.G.J., Martens, G.J.M., & Verhofstad, A.A.J. (2001) Progressive histopathological changes in pancreatic islets of Zucker Diabetic Fatty rats. Exp. Clin. Endocrinol. Diabetes 109, 273-282.




  1. Van den Hurk, W.H., Bloemen, M. & Martens, G.J.M. (2001) Expression of the gene encoding the -amyloid precursor protein APP in Xenopus laevis. Mol. Brain Res. 97, 13-20.




  1. Kuiper, R.P., Bouw, G., Janssen, K.P.C., Rötter, J., Van Herp, F., Martens, G.J.M. (2001) Localization of p24 putative cargo receptors in the early secretory pathway depends on the biosynthetic activity of the cell. Biochem. J. 360, 421-429.




  1. Schoonderwoert, V.Th.G. & Martens, G.J.M. (2002) Structural gene organization and evolutionary aspects of the V-ATPase accessory subunit Ac45. Biochem. Biophys. Acta 1574, 245-254.




  1. Schoonderwoert, V.Th.G. & Martens, G.J.M. (2002) Targeted disruption of the mouse gene encoding the V-ATPase accessory subunit Ac45. Mol. Membr. Biol. 19, 67-71.




  1. Rötter, J., Kuiper, R.P., Bouw, G. & Martens, G.J.M. (2002) Cell-type specific and selectively induced expression of members of the p24 family of putative cargo receptors. J. Cell Science 115, 1049-1058.




  1. Kramer, B.M.R., Cruijsen, P.M.J.M., Ouwens, T.W.M., Coolen, M.W., Martens, G.J.M., Roubos, E.W. and Jenks, B.G. (2002) Evidence that brain-derived neurotrophic factor acts as an autocrine factor on pituitary melanotrope cells of Xenopus laevis. Endocrinology 143, 1337-1345.



  1. Janssen, S.W.J., Hoenderop, J.G.J., Hermus, A.R.M.M., Sweep, C.G.J., Martens, G.J.M. & Bindels R.J.M. (2002) Expression of the novel epithelial Ca2+ channel, ECaC1, in rat pancreatic islets. J. Histochem. and Cytochem. 50, 789-798.




  1. Schoonderwoert, V.Th.G., Jansen, E.J.R. & Martens, G.J.M. (2002) The fate of the newly synthesized V-ATPase accessory subunit Ac45 in the secretory pathway. Eur. J. Biochem. 269, 1844-1853.




  1. Jongsma, J., Oomen, M., Noordzij, M.A., Van Weerden, W.M., Martens, G.J.M., Van der Kwast, Th.H., Schröder, F.H. & Van Steenbrugge, G.J. (2002) Different profiles of neuroendocrine cell differentiation evolve in the PC-310 human prostate cancer model during long-term androgen deprivation. Prostate 50, 203-15.




  1. Jansen, E.J.R., Holling, Van Herp & Martens, G.J.M. (2002) Transgene-driven protein expression specific to the intermediate pituitary melanotrope cells of Xenopus laevis. FEBS Letters 516, 201-207.




  1. Jenks, B.G., Ouwens, D.T.W.M., Coolen, M.W., Roubos, E.W & Martens, G.J.M. (2002) Demonstration of postsynaptic receptor plasticity in a neuroendocrine interface. J. Neuroendocrinol. 14, 843-845.




  1. Bodmer, D.,Van den Hurk, W.H., Van Groningen, J.J.M, Eleveld, M.J., Martens, G.J.M., Weterman, M.A.J. & Geurts van Kessel, A. (2002) Understanding familial and non-familial renal cell cancer. Human Molecular Genetics 11, 2489-2498.




  1. Devreese, B., Janssen, K.P.C., Vanrobaeys, F., Van Herp, F., Martens, G.J.M. & Van Beeumen, J. (2002) Automated nanoflow liquid chromatography-tandem mass spectrometry for a differential display proteomic study on Xenopus laevis neuroendocrine cells. J. Chromatography A 976, 113-121.




  1. Bosch, R.R., Janssen, S.W.J., Span, P.N., Olthaar, A.J., Van Emst-De Vries, S.E., Willems, P.H.G.M., Martens, G.J.M., Hermus, A.R.M.M. & Sweep, C.G.J. (2003) Exploring levels of hexosamine biosynthesis pathway intermediates and protein kinase C isoforms in muscle and fat tissue of Zucker Diabetic Fatty rats. Endocrine 20, 247-252.




  1. Roubos, E.W., Spooren, W.P.J.M., Veening, J.G., Martens, G.J.M. & Cools, A. (2003) Neuropeptide Y-mRNA expressions in the nucleus accumbens, caudate putamen and cerebral cortex of apomorphine-susceptible and apomorphine-unsusceptible rats. Cell Tissue Res. 313, 209-215.




  1. Janssen, S.W.J., Martens, G.J.M., Sweep, C.G.J, Span, P.N., Verhofstad, A.A. & Hermus, A.R.M.M. (2003) Phlorizin treatment prevents the decrease in plasma insulin levels but not the progressive histopathological changes in the pancreatic islets during aging of Zucker diabetic fatty rats. J Endocrinol. Invest. 26, 508-515.




  1. Martens, G.J.M. (2003) Xenopus Genomics. Current Genomics 4, 633-634.




  1. Dirks, R.P.H., Bouw, G., Van Huizen, R., Jansen, E.J.R. & Martens, G.J.M. (2003) Functional genomics in Xenopus laevis: towards transgene-driven RNA interference and cell-specific transgene expression. Current Genomics 4, 699-711.




  1. Martens, G.J.M. (2004) Peptide Hormones, Intracellular Transport. Encyclopedia of Endocrine Diseases (Martini, L., ed.); Academic Press, San Diego, CA, USA. Vol. 3




  1. Bouw, G., Van Huizen, R., Jansen, E.J.R. & Martens, G.J.M. (2004) A cell-specific transgenic approach in Xenopus reveals the importance of a functional p24 system for a secretory cell. Mol. Biol. Cell 15, 1244-1253.




  1. Collin, R.W.J., Van Strien D., Leunissen, J.A.M. & Martens, G.J.M. (2004) Identification and expression of the first non-mammalian amyloid- precursor-like protein APLP2 in the amphibian Xenopus laevis. Eur. J. Biochem. 271, 1906-1912.




  1. Van der Graaf, M., Janssen, S.W.J., Van Asten, J.J.A, Hermus, A.R.M.M. Sweep, C.G.J., Pikkemaat, J.A., Martens, G.J.M. & Heerschap, A. (2004) Metabolic profile of the hippocampus of Zucker Diabetic Fatty rats assessed by 1H Magnetic Resonance Spectroscopy. NMR in Biomed. 17, 405-10.




  1. Van den Hurk, W.H., Martens, G.J.M., Geurts Van Kessel, A. & Van Groningen, J.J.M (2004) Isolation and characterization of the Xenopus laevis orthologs of the human papillary renal cell carcinoma-associated genes PRCC and MAD2L2 (MAD2B). Cytogenet Genome Res. 106, 68-73.




  1. Doerwald, L., van Rheede, T., Dirks, R.P., Madsen, O., Rexwinkel, R., Van Genesen, S.T., Martens, G.J., de Jong, W.W. and Lubsen, N.H. (2004) Sequence and functional conservation of the intergenic region between the head-to-head genes encoding the small Heat Shock Proteins B-crystallin and HspB2 in the mammalian lineage. Journal of Mol. Evolution 59, 674 – 686.




  1. Coolen, M.W., Van Loo, K.M.J., Van Bakel, N.N.H.M., Pulford, D.J., Serneels, L., De Strooper, B., Ellenbroek, B.A., Cools, A.R. & Martens, G.J.M. (2005) Gene-dosage effect on γ-secretase component Aph-1b in a rat model for neurodevelopmental disorders. Neuron 45, 497-503.




  1. Serneels, L., Dejaegere, T., Craessaerts, K., Horré, K., Jorissen, E., Tousseyn, T., Hébert, S., Coolen, M., Martens, G., Zwijsen, A., Annaert, W., Hartmann, D. & De Strooper, B. (2005) Differential contribution of the three Aph1 proteins to -secretase activity in vivo. Proc. Natl. Acad. Sci. USA 102, 1719-1724.




  1. Van Herp, F., Coenen, T., Geurts, H.P., Janssen, G.J. & Martens, G.J.M. (2005) A fast method to study the secretory activity of neuroendocrine cells at the ultrastructural level. J Microsc. 218, 79-83.




  1. Collin, R.W.J., Van den Hurk, W.H. & Martens, G.J.M. (2005) Biosynthesis and differential processing of two pools of APP in a physiologically inducible neuroendocrine cell. J. Neurochem. 94, 1015-1024.




  1. De Groot, D.M. & Martens, G.J.M. (2005) Expression of neuroserpin is linked to neuroendocrine cell activation. Endocrinology 146, 3791-3799.




  1. De Groot, D.M., Pol, C. & Martens, G.J.M. (2005) Comparative analysis and expression of neuroserpin in Xenopus laevis. Neuroendocrinology 82, 11-20.




  1. Collin, R.W.J. & Martens, G.J.M. (2005) The amyloid- precursor-like protein APLP2 and its relative APP are differentially regulated during neuroendocrine cell activation. Molecular and Cellular Neuroscience 30, 429-436.




  1. Penning, L.C., Piek, C.J., Eib, D.W., Schipper, R.G., Holling, T.M. & Martens, G.J.M. (2006) Induction of apoptosis in hematopoietic cells with an antibody against tomoregulin-1. Anticancer Res. 26, 339-346.




  1. Coolen, M.W., Van Loo, K.M.J., Van Bakel, N.N.H.M., Ellenbroek, B.A., Cools, A.R. & Martens, G.J.M. (2006) Reduced Aph-1b expression causes tissue- and substrate-specific changes in gamma-secretase activity in rats with a complex phenotype. FASEB Journal 20, 175-177. (published online October 25, 2005).




  1. Van Rosmalen, J.W.G., Born, J.M. & Martens, G.J.M. (2006) Prion protein mRNA expression in Xenopus laevis: no induction during melanotrope cell activation. Brain Research 1075, 20-25.




  1. Van Rosmalen, J.W.G. & Martens, G.J.M. (2006) Cell-specific transgene expression of the prion protein in Xenopus intermediate pituitary cells. FEBS Journal 273, 847-862.




  1. Collin, R.W.J. & Martens, G.J.M (2006) The coding sequence of the amyloid- precursor protein APP contains a neural-specific promoter element. Brain Research 1087, 41-51.




  1. Coolen, M.W., Van Loo, K.M.J., Ellenbroek, B.A., Cools, A.R. & Martens, G.J.M. (2006) Ontogenic reduction of Aph-1b mRNA and gamma-secretase activity in rats with a complex neurodevelopmental phenotype. Mol. Psychiatry 11, 787-793. (with cover figure of study) (published online 2006 May 23, 2006).




  1. De Groot, D.M., Coenen, A.J.M., Verhofstad, A., Van Herp, F. & Martens, G.J.M. (2006) In vivo induction of glial cell proliferation and axonal outgrowth and myelination by brain-derived neurotrophic factor. Mol. Endocrinology 20, 2987-2998.




  1. Van Rosmalen, J.W.G. & Martens, G.J.M. (2007) Transgene expression of prion protein induces crinophagy in intermediate pituitary cells. Dev Neurobiol. 67, 81-96.




  1. Van Rosmalen, J.W.G. & Martens, G.J.M. (2007) Mutagenesis studies in transgenic Xenopus intermediate pituitary cells reveal structural elements necessary for correct prion protein biosynthesis. Dev Neurobiol. 67, 715-727.





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